Khedrup Gelek Pelzang, 1st Panchen Lama (1385–1438 CE) – better known as Khedrup Je –  was one of the main disciples of Je Tsongkhapa, whose reforms to the Kadam tradition of Atiśa are considered the beginnings of the Gelug school of Tibetan Buddhism.

Khedrub Je is considered to be an emanation of Manjusri, the Buddha of Wisdom. Khedrub Je was posthumously decided by the 5th Dalai Lama to have been a previous incarnation of Lobsang Chökyi Gyaltsen, 4th Panchen Lama (1570–1662). Like all the Panchen Lamas, he is considered to be an incarnation of Amitābha Buddha. Traditionally, there were considered to be four Indian and three Tibetan incarnations before Khedrup, starting with Subhuti, one of the original disciples of Gautama Buddha.

According to the legend, after Tsongkhapa died in 1419, his disciple Khedrub Jey on five occasions met with him in mystical states. Kedrub Jey is most remembered for his charisma as a teacher, as well as for the many excellent commentaries that he wrote on the tantric lineages which Tsongkhapa gathered together and elucidated. He played an important role in the education of the First Dalai Lama, who was the youngest of Tsongkhapa's five chief disciples.

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