My attempts of printing this in ABS have yielded good, smooth results but layers around the sides and at the bridge of the nose have seperated on occasion. I have not tried to print this PLA yet but I suspect that it would be much easier to achieve a flawless print.
The teeth and horns are probably the hardest to print as they are tall and or have relatively little surface area. unless you are fine with printing them flat and sanding the daylights out of them.
Personally I have been having a good time with ABS in a fully enclosed CR-10. With a bed at 90C and a hotend at 250C but these settings are of course subjective to your own choice in filament.
In terms of support it does need some, and using Cura's default Tree supports have done wonders to reduce the amount of time and material needed to print the main skull. blocking supports from areas such as the eye holes and attachment points at the sides and top of the mask is advised